Protective role of supplemental vitamin E on brain acetylcholinesterase activities of rabbits fed diets contaminated with fumonisin B1
Journal Title: European Journal of Biological Research - Year 2016, Vol 6, Issue 2
Abstract
Forty-nine rabbits were used to evaluate the protective potential of an antioxidant, vitamin E, against the negative impact of fumonisin B1 (FB1) on acetylcholinesterase (AChE) activities in the brain regions. The animals were randomly assigned to a control diet without FB1 and six diets containing different concentrations of dietary FB1 or in combination with vitamin E (i.e. 2.5 mg FB1, 5.0 mg FB1, 7.5 mg FB1, 2.5 mg FB1 + 100 mg vitamin E, 5.0 mg FB1 + 100 mg vitamin E, and 7.5 mg FB1 + 100 mg vitamin E per kg of complete feed) (n = 7 rabbits/treatment group). After 10 weeks of feeding the respective diets, the animals were sacrificed; and the brains obtained were carefully dissected out. The AChE activities in the pons of rabbits exposed to diets containing > 5 mg FB1/kg were significantly (p < 0.05) lower than those in other treatment groups. The AChE activities in the amygdala of rabbits exposed to diets contaminated with FB1 were significantly (p < 0.05) lower than those in other treatment groups. There was significant (p < 0.05) reduction in the activities of AChE in the hippocampus and the medulla oblongata of the rabbits with increase contamination level of FB1. The potential of vitamin E to combat the effect of FB1 on the brain regional AChE and specific AChE activities reduced with increase in the dietary FB1.
Authors and Affiliations
Francis Ayodeji Gbore, Olufemi A. Adu, Emmanuel O. Ewuola
Keywords
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