SCAFFOLD: TISSUE ENGINEERING AND REGENERATIVE MEDICINE
Journal Title: International Research Journal of Pharmacy (IRJP) - Year 2011, Vol 2, Issue 12
Abstract
Scaffolds are the central components, which are used to deliver the cells, drug and gene into the body. Polymeric scaffolds may be prepared as typical 3-D porous matrix, nanofibrous matrix, thermo sensitive sol-gel transition hydrogel or porous microsphere, which provide suitable substrate for cell attachment, cell proliferation, differentiated function, and cell migration. Scaffold matrices have specific advantage over other novel drug delivery systems by achieving high drug loading. This study has been conducted to illustrate the various fabrication techniques of scaffold like Particulate leaching, freeze-drying, Supercritical fluid technology, thermally induced phase separation, Rapid prototyping, powder compaction, sol-gel, melt moulding etc. These techniques allow the preparation of porous structures with regular porosity. The main conclusion of this study is Scaffold provides adequate signals (e.g., through the use of adhesion peptides and growth factors) to the cells, to induce and maintain them in their desired differentiation stage and for their survival and growth and their successful utilisation in various fields like bone formation, joint pain inflammation, tumor, periodontal regeneration, In-vivo generation of dental pulp, diabetes, osteochondrogenesis, wound dressing, inhibit bacterial growth, heart disease, repair of nasal and auricular malformation, cartilage development, regulated non-viral gene delivery, as artificial corneas, as heart valve, antiepileptic effect, tendon repair, ligament replacement, plasmid delivery, etc.
Authors and Affiliations
Tarun Garg , Ajay Bilandi , Bhawna Kapoor , Sunil Kumar , Ravi Joshi
Keywords
Related Articles
- EP ID EP119534
- DOI -
- Views 104
- Downloads 0
IN VITRO EVALUATION OF ANTIOXIDANT ACTIVITY OF SKIMMIA ANQUETILIA LEAVES EXTRACTS
The purpose of the present study is to evaluate in vitro antioxidant and free radical scavenging potential of different organic and aqueous fractions of Skimmia anquetilia Tayl. Initially the phytochemical constituents o...
PHYTOCHEMICAL SCREENING AND THE EVALUATION OF THE ANTIOXIDANT, TOTAL PHONELIC CONTENT AND ANALGESIC PROPERTIES OF THE PLANT PANDANUS FOETIDUS (FAMILY: PANDANACEAE)
Pandanus foetidus is an important medicinal plant having widespread application in a variety of disorders. The aim of this study was the phytochemical investigation and evaluation of the anti-oxidant, total phenolic cont...
METHOD DEVELOPMENT AND VALIDATION FOR THE ESTIMATION OF ATENOLOL IN TABLET DOSAGE FORM BY RP-HPLC METHOD
A simple, rapid, precise and accurate reverse phase high performance liquid chromatography has been developed and validated for the estimation of Atenolol in tablet formulations. Separation was carried on Waters e 2695 I...
DEVELOPMENT AND VALIDATION OF UV SPECTROPHOTOMETRIC ESTIMATION OF EBASTINE IN BULK AND TABLET DOSAGE FORM USING AREA UNDER CURVE METHOD
The aim of this work is to develop a simple, accurate, reproducible and cost effective spectrophotometric method for determination of Ebastine in bulk and pharmaceutical dosage form. This method is basedon area under cur...
ROLE OF NASYA AND SHIROABHYANGA IN THE MANAGEMENT OF ARUNSHIKA (DANDRUFF): A CASE STUDY
Dandruff due to fungus is extremely common, affecting close to 50% of the world's population and it also most prevalent between ages 15 and 50. This study has been conducted to come up With help of Ayurveda, we can give...