Study of influence of surface-active substances сoncentration on diltiazem releasing from rectal suppositories
Journal Title: Фармацевтичний журнал - Year 2015, Vol 1, Issue 1
Abstract
Diltiazem is one of the most widely used calcium antagonist in clinical practice. The results of its action are the lowering of myocardium oxygen need, improvement of the coronary blood flow and reducing of arterial pressure. Side effects of its oral and injection administration can be smoothed over by the transmucosal administration of diltiazem, in particular rectal with using of suitable dosage forms. The aim of this work is study of influence of surface-active substances (distilled monoglycerides) concentration on diltiazem releasing from rectal suppositories on factory fatty base which was carried out by the Kruvchinsky’s equilibrium dialysis method. Concentration of diltiazem in dialysates was determined by the spectrophotometric method. As a result of carried out biopharmaceutical investigation it was determined that concentration of the distilled monoglycerides in amount of 2% from suppository mass provided with optimal level of diltiazem releasing from a rectal dosage form.
Authors and Affiliations
K. R. Kuchina, V. V. Gladyshev, I. L. Kechin, I. A. Biruk
Keywords
Related Articles
- EP ID EP574820
- DOI -
- Views 62
- Downloads 0
Determination of esters and amides of aminobenzoic acid in the composition of finished dosage forms with acidic monoazo-dye tropaeolin O
Esters of aminobenzoic acid are widely used in medical practice as effective painkillers of local action, and its amide as is an antiarhythmic drug. The peculiarity of these drugs, in terms of analytical control, is a lo...
Study of compatibility of filter materials with solution of meloksmkama for injections
One of pharmaceutical design of parenterally solutions times is establishment of influence of filter materials on quality of preparation and choice of optimum filter membranes on the basis of these researches, establishm...
Compliance assessment of pharmacist educational program with labor-market reqiurements
The competitiveness of graduates in the labor-market is determined both by the knowledge, skills and abilities that students obtain in college and by the level of competence development – the ability to use them in pract...
Analysis of stomatological medicines assortment in Ukraine
Inflammatory periodontal diseases are one of the most common human diseases according to the WHO data. Thus, the purpose of investigation is to study the assortment of stomatological drugs intended for treatment of infla...
Electronic online system «Likipedia»
According to the position of leading Ukrainian scientists they are developing the centralized database according to the directions of its implementation. Due to the literature review some specialists focus on the absence...