Study of serum GGT and ALT levels as markers of oxidative stress in type 2 diabetes mellitus
Journal Title: Medpulse International Journal of Biochemistry - Year 2018, Vol 5, Issue 3
Abstract
Context: The role of oxidant stress in the causation of Diabetes mellitus is increasingly being recognized. Very recently it has also been shown that hypoglutathionaemia and increased oxidative stress appear to be early biochemical aberrations in Diabetes and through protein alterations, oxidative stress and redox modifications may contribute to pathogenesis of diabetic microangiopathy. Increased erythrocyte glutathionylatedHb (HbSSG) levels with decreased glutathione (GSH) was shown to be associated with Diabetes Mellitus indicating that the increased oxidative stress may be one of the implicating factors in pathogenesis of Type 2 Diabetes Mellitus. Objective: To estimate serum GGT and ALT levels in type 2 diabetes mellitus and to correlate it with normal population Material and Methods: This study was conducted in ESIC hospital. Thirty five patients reporting to the OPD diagnosed for type 2 diabetes between the age group of 50-60 years of both sex (cases) and thirty five healthy age and sex matched individuals (control) were included in the study. Under aseptic precaution blood samples were collected and centrifuged to get serum and were used for estimation. Data were analysed by student t test and values expressed as the mean ± SD and Pearson’s correlation coefficient is calculated to evaluate the relationship between 2 groups. Results: The result of the present study showed that serum GGT and ALT levels are raised in type 2 diabetes but GGT levels was significantly raised(p<0.01) in type 2 diabetes. Conclusion: Oxidative stress plays a major role in pathogenesis of Diabetes mellitus and in our study it is found that serum GGT is more reliable marker of oxidative stress than ALT. Hence serum GGT can be used for assessment and monitoring the complications of diabetes.
Authors and Affiliations
Shravan Kumar, Bhuvanendranath H
Keywords
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Study of serum GGT and ALT levels as markers of oxidative stress in type 2 diabetes mellitus
Context: The role of oxidant stress in the causation of Diabetes mellitus is increasingly being recognized. Very recently it has also been shown that hypoglutathionaemia and increased oxidative stress appear to be early...