The efficacy and adverse effect profile of lithium versus Divalproex sodium in the treatment of patients with bipolar affective disorders on combination therapy - A comparative, naturalistic, clinical study
Journal Title: Medpulse International Journal of Pharmacology - Year 2018, Vol 6, Issue 3
Abstract
Objective: To compare the efficacy of Lithium versus Divalproex sodium in the treatment of patients with bipolar affective disorder on combination therapy. Methods: A prospective, comparative study was done comparing the efficacy of Lithium versus Divalproex sodium in the Treatment of Bipolar Disorder. Patients aged between 18 to 65 years of age of either sex diagnosed with Bipolar Disorder were included in the study. Efficacy was analysed using the YMRS scale at Baseline and at the end of 4 weeks. Results: A total 68 Bipolar Disorder patients with current episode mania, wereincorporated in the study. They were divided into 2 groups. One group was on Divalproex sodium and the other group on Lithium. The concurrently administered drugs were comparable between both the groups. A total of 50 patients were males and 18 patients were females. YMRS scoring was done at baseline and at the end of 4weeks. In the Divalproate sodium group the YMRS scores at baseline and at 4 weeks were 31.22 and 29.13 respectively. In the Lithium group the YMRS scores at baseline at and 4 weeks were 30.88 and 28.93 respectively. In both the groups there was a significant reduction in the YMRS scores in 4weeks with a p value of less than 0.05. However when the YMRS scores were compared between the two groups at the end of 4 weeks there was no statistical difference. The efficacy was same in both the groups. Conclusion: Both Lithium and Divalproate Sodium were equally fficacious in the treatment of Bipolar disorder at the end of 4 weeks of treatment. Patients showed significant improvement with both the drugs at the end of 4 weeks.
Authors and Affiliations
Rovin C Vincent, Vijayalaxmi MK, Nicole Pereira
Keywords
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