A Study on Biochemical Predictors of Left Ventricular Diastolic Dysfunction in Patients with Type 2 Diabetes Mellitus
Journal Title: INTERNATIONAL JOURNAL OF SCIENTIFIC STUDY - Year 2017, Vol 5, Issue 9
Abstract
Background: The prevalence of coronary artery disease (CAD) is nearly 3 times more common in diabetes mellitus (DM) patients than in non-DM patients. Impaired glucose tolerance can be considered as a major risk factor of CAD. Hyperinsulinemia is one of the conditions of abnormal glucose metabolism significantly affects atherosclerosis development. Aim of the Study: This study aims to determine the risk factors in the onset of the left ventricular diastolic dysfunction (LVDD) within 4 years of follow-up of patients with Type 2 DM (T2DM). Materials and Methods: A total of 48 patients with T2DM were subjected to baseline fasting blood samples for fasting blood sugar (FBS), high sensitive C-reactive protein (hsCRP), hemoglobin A1c (HbA1c), and triglycerides (TG) levels. Resting transthoracic two-dimensional echocardiography and Doppler imaging to assess LVDD, left ventricular myocardial index (LVMI), and left ventricular mass at baseline and annually for 24 months was done in all the patients. Diastolic function was categorized based on mitral inflow and Doppler tissue imaging parameters. All the data were analyzed using standard statistical methods. Observations and Results: Among 48 patients with T2DM aged 45–70 years, the mean age was 56.34 ± 35; 26 males and 22 females with a male-to-female ratio of 1.8:1. Baseline body mass index was 28.97 ± 3.60, mean FBS was 128 ± 6.21, and mean HbA1c was 7.5 ± 1.21. The mean duration of T2DM in the patients was 7.23 ± 3.10 years. Conclusions: The baseline hsCRP and TG levels can predict the presence of LVDD within 24 months in Type 2 diabetes patients with previously normal systolic and diastolic cardiac function, whereas angiotensin receptor blocker therapy might have a protective role.
Authors and Affiliations
S Aiswarya
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