Design and characterization of novel calcium alginate/xanthan gum beads of ketoprofen
Journal Title: Journal of Pharmacy Research - Year 2011, Vol 4, Issue 10
Abstract
Ketoprofen is a widely used non steroidal anti inflammatory drug for the treatment of rheumatoid arthritis, ankylosing spondilities. The drug is reported to cause irritation to the stomach which may attract poor patient compliance. Development of ketoprofen controlled release micro beads using newer polymeric composition like sodium alginate and xanthan gum and to investigate the influence of polymer concentration on the properties of the beads may overcome the poor patient compliance due to gastric irritation. The micro beads were prepared by the ionotropic gelation of sodium alginate and xanthan gum in calcium chloride solution. The prepared micro beads were evaluated mainly for the sustain release of the drug (in vitro release studies) and to evaluate the micro beads for micromeritics studies, swelling index, apart from the other tests like, % drug encapsulation, particle size and drug polymer compatibility by the FTIR studies. The method had resulted in good encapsulation efficiency and micron sized alginate spheres.
Authors and Affiliations
1 N . S h e e l a , 1 B. Vi jayakumar , 2K. Bhaskar Reddy, 2 N. saravanan, 3 S . Na r e n d i r a n & 4 E. Mohanambal 2 *
Keywords
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