Regulation of diisodecyl phthalate plasticizer in the air of working zone
Journal Title: Український журнал сучасних проблем токсикології - Year 2018, Vol 84, Issue 4
Abstract
Objective. Based on the analysis and compilation of the literature data and own studies on toxicological characteristics of diisodecyl phthalate plasticizer, substantiation of its tentative safe exposure level in the air of the working zone was performed. Materials and Methods. Regulation of diisodecyl phthalate in the air of the working zone was performed based on the analytical review of the scientific publications, reference database of scientific libraries and PubMed text database of publication, as well as own results of studies of the toxicological properties of diisodecyl phthalate and its homologs under different ways of penetration of experimental animals in conditions of acute, subacute, subchronic, chronic experiments, carcinogenicity and mutagenicity, effect on reproductive function and embryogenesis, as well as investigation of its toxicodynamics and toxicokinetics was used. The resulting experimental findings were confirmed by the epidemiological studies. Results. This work provides substantiation of tentative safe exposure level (TSEL) of diisodecyl phthalate in the air of the working zone. Conclusion. For prevention of the possible negative effect on the body of workers, TSEL of diisodecyl phthalate in the air of working zone is 1.0 mg/m3, physical state — vapour + aerosol, with a mark + (Order of the Ministry of Health of Ukraine No. 1257 as of 13.10.2017 registered with the Ministry of Justice of Ukraine under No. 1353/21221 as of07.11.2017).
Authors and Affiliations
А. V. Kharlamova, V. F. Bogoyavlenska, O. G. Bychova
Keywords
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- EP ID EP521671
- DOI 10.33273/2663-4570-2018-84-4-63-70
- Views 138
- Downloads 0
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