Safety and Efficacy of a topical combination of Neomycin, Clotrimazole, Beclomethasone and Lignocaine for management of Ear Infections: Phase IV Study
Journal Title: International Journal of Medical Science and Innovative Research (IJMSIR) - Year 2017, Vol 2, Issue 3
Abstract
Introduction: Otitis or ear infection is very common in developing countries like India and is often due mixed pathogens. Multi-drug therapy is often used in the treatment of Otitis. We studied the safety and efficacy of one such combination of anti-bacterial (Neomycin), anti-fungal (Clotrimaole), steroid (Beclomethasone) and local anaesthetic (Lignocaine) in the treatment of middle and external ear infections. Methodology: Total 196 patients were enrolled out of which 160 patients completed the study. Efficacy assessment was made by reduction in Total Symptom Score (TSS) of ear pain, ear discharge and ear itching related to Otitis media with perforation and Otitis Externa. Safety assessment was made by analysing the adverse events through the study. Results: Reduction in mean TSS score was done from 5.73(baseline) to 2.19(day 3) to 0.21(day 5) of ear pain, from 5.63 (baseline) to 1.73 (day 3) to 0.15(day 5) of ear discharge and from 4.84 (baseline) to 1.48(day 3) to 0.13(day 5) of ear itching. Nearly all the patients had >50% reduction in their TSS at all visits in all the parameters. 21 episodes of adverse events occurred and all of them were of mild intensity. Conclusion: A combination of Neomycin, Clotrimazole, Beclomethasone Dipropionate and Lignocaine is safe and effective in the treatment of mixed infection of the external and middle ear (with perforation).
Authors and Affiliations
Dr. Mayuresh Kiran
Keywords
Related Articles
- EP ID EP493928
- DOI -
- Views 113
- Downloads 0
Impact of personalization of Teaching and Learning methods for UG students grouped by different Deha Prakriti (Body Constitutions)
In an effort to provide medical and technical education to build health professionals with additional insight of MET. This study focuses on how to better meet the individual education needs of the learner. This study sou...
An Epidemiological Study on Topical Steroid Misuse in Various Dermatoses.
Background: Topical corticosteroids, being one of the most frequently prescribed classes of drugs in clinical practice today, are very often subjected to misuse. A vast majority of the patients are unaware of the untowar...
Estimation of Blood Glucose as an Indirect Assessment For Attenuation Of Stress Response By Dexmedetomidine Versus Fentanyl Premedication During Laparoscopic Appendectomy: A Clinical Study
Background: Anaesthesia and surgery-induced neuroendocrine stress response can be modulated by appropriate premedication. The present study was done to assess the clinical efficacy of dexmedetomidine versus fentanyl prem...
Efficacy of Complementary Alternative Medicine (Ayurveda) In Combating Adverse Effects Associated With Chemo-Radiation
Uncontrolled proliferation of cells and metastasis are the main characteristics of cancerous cell. Surgery, chemotherapy and radiation therapy are the three modalities used in treatment of cancer alone or in combination...
Characterization and management of β- lactamases producing Escherichia coli causing complicated UTIs in an era of antimicrobial resistance
Urinary tract infections (UTIs) are among the most common infectious diseases in the community as well in healthcare settings.1 A complicated UTI is defined as an infection of urinary tract that is associated either with...