The circadian rhythms of 6-Sulfatoxymelatonin urine excretion in patients with knee osteoarthrosis
Journal Title: Український терапевтичний журнал - Year 2018, Vol 0, Issue 1
Abstract
Оbjective — to establish the peculiarities of the circadian rhythms of 6-sulfatoxymelatonin (6-SMT) urine excretion in patients with knee osteoarthrosis (OA) depending on age, gender, duration and stage of the disease. Materials and method. Examinations involved 141patients with knee OA (from them 76.6 % females), aged (58.4 ± 7.91) years with a disease duration of (10.5 ± 6.5) years. In 33.3 % of patients, gonarthrosis was combined with coxarthrosis. The OA was diagnosed based on ACR (1991) and EULAR (2010) criteria. The 6-SMT urine levels were measured with the use of 6-Sulfatoxymelatonin ELISA kit (Buhlmann, Sweden). Results and discussions. The following results have been received for patients with the knee OA: decrease in the nocturnal and mid-day 6-SMT excretion levels (34.8 % and 29.4 %), decrease in the ratio of night / day excretion by 27.1 % compared to practically healthy subjects (p < 0.001) in patients with knee joint OA. The subjects with low 6-SMT excretion (creatinine < 13.7 ng/mg) were more common for patients over 60 (in 2.14 times, p < 0.01) and for patients with Stage III OA (in 2.89 times, p < 0.01). More pronounced decrease in 6-SMT excretion (by 13.0 %) was revealed in patients with combination of gonarthrosis and coxarthrosis. The level of 6-SMT excretion had statistically significant association with the age of patients and duration of the disease (r = –0.40; –0.18, p < 0.05) rather than with the synovitis diagnosis. Conclusions. Decrease in 6-SMT excretion in OA patients suggests of a disturbance of the circadian rhythms of melatonin production and is a potential factor of progression of the destructive and dystrophic changes in the articular tissues.
Authors and Affiliations
O. V. Humeniuk, M. A. Stanislavchuk, N. V. Zaichko
Keywords
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